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Use Support Systems Support from family, friends, or healthcare professionals can make quitting easier

Harm Reduction When reviewing the evidence on what is known about e-cigarette exposure and health effects compared with conventional tobacco cigarettes, the committee found: Conclusive evidence that completely substituting e-cigarettes for conventional cigarettes reduces user exposure to numerous toxic substances and carcinogens present in conventional cigarettes

Large population-based studies that can evaluate these associations across sociodemographic subgroups are needed to clarify these aspects, particularly regarding the trajectory over time of the association between smoking behaviors and cessation with depression outcomes [24]

Tobacco blend analysis Tobacco blends used in the ECs described in this work were analysed for nicotine, sugars, total and protein nitrogen, polyphenols, metals, TSNAs, and benzo[a]pyrene (Additional file1: Table S6)