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Moreover, in a xenograft mammary 4T1 tumor model, it has been demonstrated that the concurrent administration of BAPN and the enzyme-responsive drug (NQO1-SN38), designed to target breast tumors with the topoisomerase I inhibitor SN38, results in a cooperative reduction in tumor growth [100]

Notably, there was no difference in the TNF protein expression of between BRCA and normal tissues in TCGA database, which possibly due to the abnormal expression of TNF in physiological or pathological states such as the inflammatory response and immune regulation 47