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5,61 As an example, orally administered GSH ethyl ester is able to significantly raise GSH concentrations in the liver, kidney, spleen, pancreas, heart, and lung of the mouse, and in human red blood cells, skin fibroblasts, and several lymphoid cell lines

The cuproptosis-related gene PDHA1 may serve as a node linking these pathways, regulating lipid metabolism through its interaction with the PI3K-Akt-mTOR signaling pathway [123] (Figure 5)

10.1124/pr.110.003889 41 BroughtonB

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