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Tobacco harm reduction strategies, which involve encouraging smokers who cannot or will not quit nicotine entirely to switch to significantly less harmful alternatives, offer a pathway to mitigate this burden

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Briefly, the studies that were extracted represented several types of study design (for example, cohort and casecontrol studies), measured exposure in several different ways and varied in their choice of reference categories (where some compared current smokers with never smokers, whereas others compared current smokers with nonsmokers or former smokers)

Prohibiting menthol in tobacco products should be a very high priority. (Agency officials declined to be interviewed