rbc glutathione reductase human Interplay between Erythrocyte Peroxidases and

miRNAs like miR-148a and miR-340 regulate pigmentation by modulating MITF and dendrite formation, while miR-21 enhances anti-apoptotic and proliferative pathways in melanocytes post-UVA exposure, indicating multifaceted roles in pigmentation and survival 104,105

VAS: Visual analogue scale

An important function of mitochondrial-generated O 2 and H 2 O 2 is the activation of cellular signaling, which is essential for stem-cell differentiation, tissue morphogenesis, lymphocyte and macrophage activation, and metabolic adaptation under nutrient deprivation

As such, it acts as a cellular signal for oxidative stress and is involved in the regulation of cellular states such as proliferation or apoptosis