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Similarly, previous studies had focused on glutamine consumption in the context of SCD, and glutamine supplementation as a therapeutic strategy to fuel de novo glutathione synthesis as a strategy to counteract oxidant stress in the sickle RBC, though findings are controversial as to whether glutamine supplementation aggravates or mitigates the incidence of pain and vaso-occlusive crises in this patient population

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Despite numerous studies during the past decades, cell-extrinsic and -intrinsic molecular mechanisms governing the dynamic metabolic changes in hepatocytes after partial hepatectomy (PH) still remain incompletely understood

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