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The absence of this protective layer of glycosaminoglycans in patients with interstitial cystitis increases inflammation, which leads to cyst formation and swelling with subsequent pain and irritation.7 In one study, approximately half of the women diagnosed with interstitial cystitis reported symptoms of dysuria.8 Other causative factors of interstitial cystitis have been suggested, including chronic or subclinical infection, autoimmunity, and genetic susceptibility, any of which could be responsible for initiating the inflammatory response

And did I mention that oxidative stress itself also increases inflammation

however, the highest glutathione content and concentration were observed at pH 4.5 (Fig

Importantly, lupus T cells exhibit mitochondrial dysfunction, which is characterized by elevated mitochondrial transmembrane potential ( m ) or persistent mitochondrial hyperpolarization (MHP) that mediates diminished activation-induced apoptosis and predisposes T cells to pro-inflammatory death via necrosis (Gergely et al