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c-KIT-mediated ERK signaling pathway can induces CREB phosphorylation to activate melanin synthesis on one hand, and on the other hand, the activation of ERK signaling has been demonstrated to phosphorylate MITF at the serine 73 residue, which leads to the ubiquitination and degradation of MITF, this is the feedback mechanism of the ERK pathway to regulate melanin production (3,35)

Experimental Neurology, 71 : 203-219), et reprise par Russell et coll

Once bound to the AR, testosterone is irreversibly converted to dihydrotestosterone (DHT) through the enzymatic action of 5- reductase (Wilborn et al., 2010)

Eur Arch Psychiatry Clin Neurosci 274 , 18291845 (2024)