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This work was supported by National Natural Science Foundation of China 82074376 and 82374388, the Specific Fund of State Key Laboratory of Dampness Syndrome of Chinese Medicine SZ2021ZZ50, Guangdong Provincial Science and Technology Project 2022A1515012051

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Thus, this epigenetic alteration is now considered as a cancer biomarker but could as well play a driving role in multistep cancer development, especially well documented in prostate cancer development