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Research interest grew substantially beginning in 2003, with annual publications reaching 39 by 2014

When the researchers exposed tadpoles to nicotine-free versions of the same flavors, those tadpoles still developed clefts in the same ratios

16 Concern was raised at a recent European Commission 27 meeting by two e-cigarette associations that there were still quality and safety issues with some products and that not all producers of electronic cigarettes were responsible manufacturers'

The overall risks associated with nicotine products include their negative impact on sleep and the potential for long-term sleep disorders