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Elevated levels of plasma biomarkers, especially markers of systemic inflammation (interleukin-6 and interleukin-8), epithelial injury (receptor for advanced glycation end products and surfactant protein D) and endothelial injury (angiopoietin 2), as well as dysregulated coagulation markers (low levels of protein C and high levels of plasminogen activator inhibitor 1), have all been associated with adverse SARS results