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The effect of exercise training on osteocalcin, adipocytokines, and insulin resistance: a systematic review and meta-analysis of randomized controlled trials

The generation of oxidative DNA lesions, such as 8-oxoguanine (8-oxoG), is linked to the development of various cancers, including melanoma, while the accumulation of these lesions can compromise genomic stability, leading to mutations and the eventual transformation of normal cells into malignant ones 53

Figure 1A shows an overview of the entire study design for the L-GSH clinical study with T2DM subjects