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Thus, as shown in Figure 16 , the (probably not surprising) conclusion is that niclosamide can readily revert to its most stable solid forms (--the monohydrates and similar cosolvates identified by van Tonder et al (2, 62)) that have a lower solubility of niclosamide in aqueous solution when in contact with these solid forms

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Genetic analysis of disulfide isomerization in Escherichia coli : expression of DsbC is modulated by RNase E-dependent mRNA processing