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Clinical outcomes The beneficial effects of riboflavin on biochemical (Reference Al-Harbi, Imam and Nadeem22,Reference Alhazza, Hassan and Ebaid23,Reference Bashandy, Ebaid and Moussa26,Reference Alam, Iqbal and Naseem31) and histopathological findings (Reference Al-Harbi, Imam and Nadeem22,Reference Alhazza, Hassan and Ebaid23,Reference Al-Harbi, Imam and Nadeem25Reference Karakoyun, Erta and Yksel27,Reference Sakarcan, Erahin and Eminolu30Reference Yu, Morimoto and Yu32) and clinical symptoms (Reference Sakarcan, Erahin and Eminolu30,Reference Yu, Morimoto and Yu32) , reported concurrent with alleviated oxidative stress in animals, suggest that riboflavin antioxidant activity may lead to promising clinical outcomes in these conditions

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FDXR deficiency (OMIM #617717) FDXR (Ferredoxin Reductase) has one FAD/NAD(P)-binding domain and two NAD(P)-binding domains