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The results indicated that the e-cigarette group exhibited a lower heart rate-corrected isovolumetric relaxation time (IVRTc) ( p = 0.011) and tissue Doppler flow (MPIt) ( p = 0.019)

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Furthermore, we found that e-cigs damage DNA not only at chromosomal level in peripheral blood, such as strand breaks in leucocytes and micronuclei formation in reticulocytes, but also at gene level such as point mutations in urine