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Moreover, an in vitro investigation revealed that glutathione peroxidase 4 (GPX4), which was the brake of ferroptosis, was reduced by SARS-CoV-2 [78]

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2 Because placebo effects are common in controlled trials conducted with IC/BPS patients, any apparent procedural deviations that could compromise the integrity of randomization or blinding resulted in a rating of increased risk of bias for that particular trial