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Together, they reduce ROS production by acting on mitochondrial respiratory Complex I

Moreover, PEITC caused a rapid depletion of mGSH and a significant elevation of ROS and NO, induced a disruption of the mitochondrial electron transport complex I, and a significant suppression of mitochondrial respiration that resulted in cytotoxicity in leukemia cells ( As mGSH is regulated by cholesterol, as described above, the trafficking of mitochondrial cholesterol may modulate cancer cell biology

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