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Also, an enzyme located in the mucous membrane of the intestines, or enterocytes, which are more susceptible to oxidant damage, can be inactivated to a larger extent leading to variation in the results of its determination

They can stimulate cell growth, inflammation, and blood flow to assist tissue recovery after injury, disease, or aging

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Recently, there is a theory explaining how NRF2 is stabilized under stress conditions, called the two-site substrate hinge and latch model. It is known that each of the two dimeric KEAP1 molecules will bind NRF2 separately through their respective Kelch repeat domain to either the ETGE or DLG motifs in NRF2