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Studies have shown that the brain, particularly the prefrontal cortex, continues developing throughout adolescence and into young adulthood.[83] The Massachusetts Institute of Technologys Young Adult Development Project explained the significance of the prefrontal cortex: The cluster of functions that center in the prefrontal cortex is sometimes called the executive suite, including calibration of risk and reward, problem-solving, prioritizing, thinking ahead, self-evaluation, long-term planning, and regulation of emotion.[84] The National Institute of Mental Health described the brain development that takes place during the teenage years: A clue to the degree of change taking place in the teen brain came from studies in which scientists did brain scans of children as they grew from early childhood through age 20

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There are only two published randomized control trials considered the gold standard of scientific evidence on e-cigarettes (this one and this one)

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