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38 It is known, however, that the major zinc-sensing transcription factors in eukaryotic cells, exemplified by vertebrate MTF-1 and Zap1p in Saccharomyces cerevisiae (Figure 3B) employ one or more ZF motifs as sensors of cellular zinc status, which results in the regulation of transcription of genes that encode enzymes that re-establish zinc homeostasis

Because of this origin, it is studied as a potential communicator between mitochondria and the rest of the cell, a role researchers refer to as retrograde mitochondrial signaling