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Likewise, anti-inflammatory actions of IGF-1 [124] can be regarded as a crucial factor protecting tissues from the deleterious effects of pro-inflammatory mediators in chronic disorders such as obesity

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The potential relationship between GLP-1 receptor agonists like semaglutide and thyroid C-cell tumors has been observed in rodent studies, where dose-dependent and duration-dependent increases in thyroid C-cell tumors were noted

Its very low molecular weight (342 Da) gives it exceptional tissue penetration, making it particularly well-suited for study in colitis and dermatitis models (Brzoska et al., Endocr Rev 2008)