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Despite the lack of a lasting effect on food intake, cagrilintide elicited a sustained and noteworthy reduction in body weight in WT mice (day 21 body weight loss: 3.4 g or 66% vs WT Veh

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Liver lesion assessment revealed necrosis, steatosis, and congestion and was scored as 03 (min/med/max), cell nuclei diameters (m), area of cell cytoplasm (m 2 ), double nuclei cell number (means SD) in untreated 24 h-short bowel-rats (SBS) and those administered diclofenac (D, 12 mg/kg intraperitoneally)