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Van Eldere et al., 2014)

doi: 10.3389/fmed.2023.1124275 Received 14 December 2022 Accepted 27 February 2023 Published 22 March 2023 Volume 10 - 2023 Edited by Ana Sandoval-Rodriguez, University of Guadalajara, Mexico Reviewed by Angelo Armandi, University of Turin, Italy

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The estimated prevalence of homocystinuria in the United States is 1 in 100,000 to 200,000, but the actual prevalence may be much higher, due to the inaccuracy of the screening test