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Importantly, 4T1 cells were almost eliminated by fasting-mimic treatment combined with Tram and DXR in vitro, indicating a synergistic anti-neoplastic effect (Supplementary Fig

P53 can inhibit cystine uptake by inhibiting the expression of SLC7A11, a vital component of the cystine/glutamate reverse transporter, thereby enhancing the sensitivity of cells to ferroptosis [32]