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A model of intracellular antigen possibly targeted by non-HLA antibodies is the glutathione S-transferase theta 1 (GSTT1) protein, a member of an enzyme superfamily, involved in cellular detoxification pathways, that represents a barrier against the damaging effects of oxidative stress ( As for other recently described donor-recipient gene polymorphism mismatches, such as the collision genotype at the LIMS1 locus ( In the present study, we retrospectively evaluated donor/recipient GSTT1 genetic profile and the kinetics of GSTT1 antibodies in a population of pediatric, non-sensitized kidney recipients systematically monitored for HLA antibodies throughout the post-transplant period, with the aim of analyzing their role in kidney graft outcome

97,98 DSBs are first detected, then the DNA ends are trimmed to form 3-ssDNA

DTNB reacts with GSH to form a yellow product that can be measured spectrophotometrically at an absorbance of 412 nm

Part of the B complex of vitamins, inositol helps to maintain neural functioning and cell structures