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She is the lone relatable voice on a show rife with scientific references and sometimes incoherent nerd jargon, a refreshing foil to geeky Caltech physicists Sheldon Cooper (Jim Parsons) and Leonard Hofstadter (Johnny Galecki), the (now-not-so) new neighbors she befriended after moving into a Pasadena, Calif., apartment complex, as well as their supersmart yet socially challenged friends: aerospace engineer Howard Wolowitz (Simon Helberg), astrophysicist Raj Koothrappali (Kunal Nayyar), physicist Leslie Winkle (Sara Gilbert), neuroscientist Amy Farrah Fowler (Mayim Bialik), microbiologist Bernadette Rostenkowski (Melissa Rauch) and comic book store owner Stuart Bloom (Kevin Sussman)