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Advanced Delivery Systems To enhance penetration and efficacy, researchers are developing: Liposome-encapsulated GHK-Cu Nanoparticle delivery systems These technologies aim to deliver the peptide deeper into the dermis , improving clinical outcomes in both cosmetic and medical applications (Pickart & Margolina, 2018)

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Setmelanotide is a disulfide cyclic synthetic peptide, eight amino acids long, capable of crossing the blood-brain barrier 37 where at its site of action in the hypothalamus, it can activate several melanocortin receptors 37