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Figure 6b shows changes in the L-2-hydroxyglutarate dehydrogenase ( L2HGDH ) pathway, which plays a key role in the metabolism of hydroxyglutarate

For regular drinkers (3+ drinks per week), daily NAC (600mg) or alpha-lipoic acid (300mg) supports baseline glutathione synthesis without suppressing endogenous production, and both have been studied in chronic alcohol use populations with positive hepatoprotective outcomes