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Around 22.3% of the worlds population, primarily in low- and middle-income countries, use tobacco, with men disproportionately affected

Paleoethnobotany: A Handbook of Procedures (Routledge, 2015)

Although only a limited number of herbicides are available for use in tobacco compared to grain crops, the herbicides that are available have generally provided adequate weed control, particularly when supplemented with cultivation

"Once you have a substance out there like tobacco in wide use it's hard to turn around and make it illegal," said Arthur Caplan, a bioethicist at New York University School of Medicine's Division of Medical Ethics, "You can certainly tax it, you can certainly stigmatize it," and educate against its use