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Statements Author contributions MS: Conceptualization, Investigation, Visualization, Writingoriginal draft, Writingreview and editing

Compared with normal hepatic function, the estimated ratio of the mean AUC 0 was 0.99 (0.891.11) in mild impairment, 1.01 (0.911.12) in moderate impairment and 1.11 (0.961.30) in severe impairment