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GHK-Cu is a potent copper complex, and a brief, mild stinging sensation at the administration site is a normal and temporary reaction for some individuals

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Table 3 presents genes that are upregulated, and Table 4 presents genes that are down regulated

Mechanistically, Nrf2 activation leads to transcriptional activation of antioxidant enzymes, including microsomal epoxide hydrolase, heme oxygense-1 (HO-1), NADPH: quinone oxidoreductase 1 (NQO-1), and glutamate cysteine ligase (GCL), which catalyzes the initial and rate-limiting step in GSH synthesis