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Mulloy JC, Cancelas JA, Filippi MD, Kalfa TA, Guo F, Zheng Y

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Increased BBB permeability suggests loss of BBB integrity evidenced by EC degeneration, TJs decrease, and pericyte deterioration and detachment from ECs

(2) in the preparation of the product, auxiliary materials such as crystal skeleton propping agent and the like are not added, and the prepared product can obtain a final product with the loading capacity and the appearance meeting the requirements, thereby eliminating the product quality risk caused by adding the auxiliary materials and improving the medication safety