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Scientific Communications: acute 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.01 - ACUTE MANAGEMENT - Neither thrombolysis nor thrombectomy O - ESOC25-1401 NEUROFILAMENT LIGHT AS A MARKER OF NEUROAXONAL INJURY IN THE ESCAPE-NEXT TRIAL Steffen Tiedt 1 , Thalia Field 2 , Gabor Petzold 3,4 , Mirko Pham 5 , Richard Swartz 6 , Sven Poli 7 , Jrg Berrouschot 8 , Atif Zafar 9 , Hauke Schneider 10 , Jai Shankar 11 , Anne Hege Aamodt 12 , Jens Minnerup 13 , Jennifer Mandzia 14 , Gernot Reimann 15 , Marios Psychogios 16 , Sibu Mundiyanapurath 17 , Arno Reich 18 , Leonard Yeo 19 , Mayank Goyal 20 , Michael Tymianski 21 , Martin Dichgans 1 , Michael Hill 1 LMU University hospital, Institute for Stroke and Dementia Research, Munich, Germany, 2 Division of Neurology, Stroke Program, University of British Columbia, Vancouver, Canada, 3 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 4 Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany, 5 Department of Neuroradiology, Wrzburg University Hospital, Wrzburg, Germany, 6 Division of Neurology, Sunnybrook Health Sciences Centre, Toronto, Canada, 7 Department of Neurology and Stroke, University Hospital Tbingen, Tbingen, Germany, 8 Klinik fr Neurologie, Klinikum Altenburger Land, Altenburg, Germany, 9 St Michael's Hospital, Toronto, Canada, 10 Department of Neurology, University Hospital Augsburg, Augsburg, Germany, 11 Department of Radiology, University of Manitoba, Winnipeg, Canada, 12 Department of Neurology, Oslo University Hospital, Oslo, Norway, 13 Department of Neurology, University Hospital Mnster, University of Mnster, Mnster, Germany, 14 Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Canada, 15 Klinikum Dortmund, Klinikum der Universitt Witten/Herdecke, Dortmund, Germany, 16 Department of Neuroradiology, University Hospital Basel, Basel, Switzerland, 17 Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany, 18 Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany, 19 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 20 Department of Diagnostic Imaging, University of Calgary, Calgary, Canada, 21 NoNO, Inc, Toronto, Canada Background and Aims: Circulating levels of Neurofilament Light (NfL) indicate neuroaxonal injury and are an established endpoint in clinical trials for chronic neurological diseases such as multiple sclerosis