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(4) Dose titration: Therapy is typically initiated at low doses and titrated gradually to achieve optimal symptom control while minimizing adverse effects, with the goal of identifying the lowest effective daily dose

At this level, our risks of alcohol-related accidents, such as falling, drowning, or falling victim to a crime, increase significantly

Similarly, earlier studies led by Sikiric and colleagues in the 1990s suggested safety and benefit in gastrointestinal conditions such as ulcerative colitis, but these reports were published only in abstracts or local conference proceedings, with no independent replication or peer-reviewed validation

Kim, S.W