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The dose escalation in days 16-30 is designed to reinforce the signaling pathways activated in Phase 1

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Children with mitochondrial-related epilepsy exhibit a higher prevalence of focal seizures and nDNA mutations compared to adults

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Using IV therapy can drive greater transport of these key mood regulating substances into the brain

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In addition, DMF treatment increased DNA 5hmC but not 5mC levels in the CBS gene promoter CpG island (Fig

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