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Thomas Gates, then McNeils medical director, shot off a memo to the chief executive of Johnson & Johnson, the president of McNeil and other top officials, laying out a detailed plan of action for diffusing media interest in the research and limiting the extent and duration of the coverage. Gates envisioned two possibilities: Low Level of Publicity (most probable scenario) and High Level of Publicity (worst case scenario). For the latter, Gates suggested a series of responses: a letter-writing campaign to medical societies, doctors, pharmacists and academics
The environmental pollutant 1, 1-dichloro-2, 2-bis (p-chlorophenyl) ethylene induces rat hepatic cytochrome P450 2B and 3 A expression through the constitutive androstane receptor and pregnane X receptor
Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora
This means it prevents any introduced bacteria from reproducing, making it safe for multi-draw research vials over a 28-day period
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