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Detoxification units, dealing with dependence on alcohol and illicit drugs, are not appropriate for prescribed benzodiazepine users who have unwittingly become dependent through no fault of their own

This suggests that cobalt sensitivity might be a contributing factor to these skin reactions

Mechanistically, lactate contributes to the intracellular acetyl-CoA pool through its conversion to pyruvate, followed by subsequent metabolism (74)

The most commonly reported adverse effects were mild to moderate headache and gastrointestinal symptoms including diarrhea, flatulence, nausea, and increased appetite