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Under strong oxidative stress, GSH is rapidly converted into GSSG, which results in a lower GSH/GSSG ratio

Schoenfeld JD, Sibenaller ZA, Mapuskar KA et al (2017) O2- and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate

& Manohar, S