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Future research should directly compare the effects of 1-MX with tri-(caffeine), di-(paraxanthine, theophylline, and theobromine) and methylxanthines (3-MX, 7-MX) as well as their combination, as these compounds have different pharmacokinetic, safety and efficacy profiles

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Under chronic stress, neurons have impaired synaptic number and function as well as diminished plasticity, which increases susceptibility to depression [44]

For fragment [1,3 A - ] ( d,e,f ) and fragment [1,3 A + ] ( g,h,i ) comprising C 4 , the incorporation of an O 18 label is not observed, while fragment [0,2 A-H2O] + ( g,h,i ), including C 3 , contains an O 18 label supporting formation of flavan-3,3,4-triol ( 4 )