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Khan et al., 2016 demonstrated that although bacteria could not be cultured from endometriomas (or other non-endometrioma cysts in controls) there was significantly more Streptococcaceae and Staphylococaceae and less Lactobacillacae in endometriomas as compared to non-endometrioma cysts from controls using 16S rRNA sequencing 77

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10.1038/ncomms14694 17 HongJ.XuB.HuX.LiuC.LiuH.TianJ.et al (2025)

The aromatic amine portion of the sulfonamide antimicrobial is considered to be critical in the development of latter 2 reactions