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Acknowledgements The authors would like to acknowledge the facilities provided by the Department of Botany (CAS Phase VII), University of Calcutta, DBT-IPLS facility, University of Calcutta for confocal microscopy facility and IM would like to thank UGC under Government of India for CSIR-UGC NET fellowship scheme

KPV, an alpha-MSH derivative, is another peptide with anti-inflammatory properties that has been studied for various inflammatory conditions

BSO had merely no effect on [-Glu-Glu] e , while SFN enhanced it, although not significantly (135 25%, n = 3)

Ideally, the targeted receptor- or carrier-mediated transport processes for brain targeting should occur exclusively at the BBB to avoid off-target delivery